Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 3/20 | 0.37 |
| ▸ | RORA | P35398 | 3/20 | 0.37 |
| ▸ | RORC | P51449 | 3/20 | 0.37 |
| ▸ | RORB | Q92753 | 3/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | RGS4 | P49798 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | RGS8 | P57771 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2207598 | 0.91 | ELANE (0.38) | ELANEALDH1A1POLBRXFP1KDM4E | |
| SCHEMBL2206340 | 0.84 | ELANE (0.40) | L3MBTL1ELANEALDH1A1LMNAHPGD | |
| SCHEMBL1523092 | 0.81 | ALDH1A1 (0.42) | ELANEALDH1A1KDM4ELMNAALOX15 | |
| SCHEMBL2207892 | 0.78 | HSD17B10 (0.39) | TDP1L3MBTL1ELANEALDH1A1RGS4 | |
| SCHEMBL1522285 | 0.77 | ALDH1A1 (0.39) | TDP1L3MBTL1PGRRORARORC | |
| SCHEMBL23412821 | 0.76 | ELANE (0.36) | ELANEADORA2B | |
| SCHEMBL1523116 | 0.74 | ERCC1 (0.34) | ELANEADORA2BERCC1ERCC5FEN1 | |
| SCHEMBL1523762 | 0.73 | ERCC5 (0.57) | ALDH1A1ADORA2BGSK3BKMT2AERCC1 | |
| SCHEMBL1061987 | 0.73 | PGR (0.60) | TDP1L3MBTL1PGRRORARORC | |
| SCHEMBL1522571 | 0.72 | ALDH1A1 (0.41) | ELANEALDH1A1ALOX15TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824843-A2 | INHIBITORS OF PROTEIN KINASES | Locus Pharmaceuticals, Inc. (US) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006062984-A2 | INHIBITORS OF PROTEIN KINASES | LOCUS PHARMACEUTICALS, INC. (US) | 2006-06-15 | — | — | WO | disclosed |