Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | UBE2N | P61088 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | FOXM1 | Q08050 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CDC25B | P30305 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5613817 | 0.88 | PTPN1 (0.44) | PTPN1MAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2200143 | 0.88 | ESRRA (0.47) | MAPTPOLBCYP3A4FOXM1MEN1 | |
| SCHEMBL2200999 | 0.88 | ESRRA (0.47) | MAPTPOLBCYP3A4FOXM1MEN1 | |
| SCHEMBL5616853 | 0.83 | FOXM1 (0.45) | PTPN1CYP1A1CYP1B1FOXM1MEN1 | |
| SCHEMBL5616931 | 0.82 | FOXM1 (0.43) | PTPN1CYP1A1CYP1B1FOXM1MEN1 | |
| SCHEMBL5613835 | 0.81 | FOXM1 (0.41) | PTPN1CYP1A1CYP1B1FOXM1MEN1 | |
| SCHEMBL5617115 | 0.80 | ESRRA (0.42) | PTPN1CYP1A1CYP1B1FOXM1MEN1 | |
| SCHEMBL5613843 | 0.79 | PTPN1 (0.43) | PTPN1FOXM1ESRRAALOX5 | |
| SCHEMBL8267384 | 0.79 | ESRRA (0.47) | MAPTSYKMEN1KMT2ACDC25B | |
| SCHEMBL5614007 | 0.79 | PTPN1 (0.45) | PTPN1FOXM1ESRRAMRGPRX4ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805154-A2 | PHARMACEUTICAL COMPOSITIONS | Exelixis, Inc. (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006047269-A2 | PHARMACEUTICAL COMPOSITIONS | EXELIXIS, INC. (US) | 2006-05-04 | — | — | WO | disclosed |