Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 9/20 | 0.58 |
| ▸ | CTSS | P25774 | 2/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5967151 | 0.94 | CTSK (0.65) | CTSKCTSS | |
| SCHEMBL8577155 | 0.94 | CTSK (0.65) | CTSKCTSS | |
| SCHEMBL7977067 | 0.94 | CTSK (0.65) | CTSKCTSS | |
| SCHEMBL18123014 | 0.88 | CTSK (0.61) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL29299766 | 0.88 | CTSK (0.61) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL23677838 | 0.87 | CTSK (0.60) | CTSKCTSS | |
| SCHEMBL14302356 | 0.87 | CTSK (0.60) | CTSKCTSS | |
| SCHEMBL7555646 | 0.86 | CTSK (0.60) | CTSKCTSS | |
| SCHEMBL1926493 | 0.86 | CTSK (0.60) | CTSKCTSS | |
| SCHEMBL5050858 | 0.86 | CTSK (0.60) | CTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786427-A2 | ALIPHATIC AMIDE & ESTER PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS | Johnson, Michael R. (US) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006023573-A2 | ALIPHATIC AMIDE & ESTER PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS | JOHNSON MICHAEL R (US) | 2006-03-02 | — | — | WO | disclosed |