Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL561601 | 1.00 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1KMT2AMAPTNPC1 | |
| SCHEMBL28888757 | 0.81 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1KMT2AMAPTNPC1 | |
| SCHEMBL561604 | 0.81 | CES2 (0.39) | SMN1; SMN2KMT2AMAPTNPC1RAB9A | |
| SCHEMBL16070867 | 0.80 | NR4A1 (0.58) | KMT2ANPC1RAB9AMEN1NR4A1 | |
| SCHEMBL16070866 | 0.80 | NR4A1 (0.58) | KMT2ANPC1RAB9AMEN1NR4A1 | |
| SCHEMBL16070868 | 0.80 | NR4A1 (0.58) | KMT2ANPC1RAB9AMEN1NR4A1 | |
| SCHEMBL556261 | 0.79 | KMT2A (0.41) | SMN1; SMN2ALDH1A1KMT2AMAPTNPC1 | |
| SCHEMBL11427406 | 0.75 | MAOB (0.50) | SMN1; SMN2ALDH1A1KMT2AMAPTNPC1 | |
| SCHEMBL11438214 | 0.74 | MAOB (0.49) | SMN1; SMN2ALDH1A1KMT2AMAPTNPC1 | |
| SCHEMBL28392269 | 0.73 | NR4A1 (0.60) | KMT2AMAPTNPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035114-A1 | INHIBITORS OF STAT3 AND USES THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035114-A1 | INHIBITORS OF STAT3 AND USES THEREOF | STAT3, JAK2, STAT6 | SMN1; SMN2 4774/4885ALDH1A1 3790/4885KMT2A 2506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.