Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 3/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17765360 | 1.00 | NR1H2 (0.44) | NR1H2NR1H3SIGMAR1ESR2CHRM2 | |
| Hydrochloric Acid SCHEMBL28296912 | 0.79 | SMN1; SMN2 (0.44) | SIGMAR1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL1534340 | 0.74 | KCNN4 (0.50) | SIGMAR1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL1534228 | 0.74 | KCNN4 (0.50) | SIGMAR1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL1534309 | 0.74 | KCNN4 (0.50) | SIGMAR1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL5616072 | 0.72 | NPC1 (0.43) | SIGMAR1ESR2CHRM2LMNAALDH1A1 | |
| SCHEMBL11324855 | 0.70 | KCNH2 (0.45) | SIGMAR1ESR2TDP1OPRM1 | |
| SCHEMBL9153842 | 0.70 | KCNH2 (0.45) | SIGMAR1ESR2TDP1OPRM1 | |
| SCHEMBL27602017 | 0.70 | KCNH2 (0.45) | SIGMAR1ESR2TDP1OPRM1 | |
| SCHEMBL599438 | 0.70 | NR1H2 (0.58) | NR1H2NR1H3ESR2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2986288-B1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE | NICOX SCIENCE IRELAND (IE) | 2017-04-12 | — | — | EP | disclosed |
| US-9598349-B2 | Quinone based nitric oxide donating compounds for ophthalmic use | NICOX SCIENCE IRELAND (IE) | 2017-03-21 | — | — | US | disclosed |
| US-20160145192-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE | NICOX SA (FR) | 2016-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160145192-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE | NQO1, NOS1, NOS2 | NR1H2 893/4885NR1H3 1202/4885SIGMAR1 3461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.