Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.37 |
| ▸ | THRA | P10827 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4900554 | 0.78 | MAPT (0.49) | TLR8ALDH1A1KMT2AMAPTCA1 | |
| SCHEMBL4908743 | 0.73 | MAPT (0.51) | TLR8ALDH1A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5600123 | 0.72 | MAPT (0.34) | TLR8ALDH1A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL9378249 | 0.71 | TLR8 (0.37) | TLR8THRATHRBALDH1A1KMT2A | |
| SCHEMBL4911325 | 0.71 | TLR8 (0.37) | TLR8THRATHRBALDH1A1KMT2A | |
| SCHEMBL4907880 | 0.70 | FYN (0.37) | ALDH1A1KMT2AMAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL4911594 | 0.67 | LMNA (0.37) | TLR8KMT2AMAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL4906658 | 0.65 | MAPT (0.38) | ALDH1A1KMT2AMAPTSMN1; SMN2POLB | |
| SCHEMBL4902316 | 0.64 | TLR8 (0.33) | TLR8ALDH1A1KMT2AMAPTPOLB | |
| SCHEMBL5299480 | 0.64 | TLR8 (0.48) | TLR8ALDH1A1KMT2APOLBHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1755678-A2 | ACTIVE SUBSTANCE COMBINATION OF A CARBINOL COMPOUND AND AN OPIOID | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-02-28 | — | — | EP | claimed |
| WO-2005097192-A2 | ACTIVE SUBSTANCE COMBINATION OF A CARBINOL COMPOUND AND AN OPIOID | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2005-10-20 | — | — | WO | claimed |