Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5248488 | 0.78 | THRB (0.36) | GAAEPHX1EPHX2ALDH1A1 | |
| SCHEMBL6860976 | 0.78 | GAA (0.38) | GAAGLAEPHX1EPHX2ALDH1A1 | |
| Bromide SCHEMBL27511892 | 0.76 | THRB (0.35) | GAAEPHX1EPHX2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL27525501 | 0.76 | THRB (0.35) | GAAEPHX1EPHX2ALDH1A1 | |
| SCHEMBL6854374 | 0.76 | EPHX1 (0.34) | GAAGLAEPHX1EPHX2ALDH1A1 | |
| SCHEMBL2849062 | 0.76 | ALDH1A1 (0.39) | GAAEPHX1EPHX2ALDH1A1NPC1 | |
| SCHEMBL4711516 | 0.71 | THRB (0.34) | GAAEPHX1EPHX2ALDH1A1 | |
| SCHEMBL4710035 | 0.70 | ALDH1A1 (0.39) | GAAGLAEPHX1EPHX2ALDH1A1 | |
| SCHEMBL31053476 | 0.70 | HTT (0.53) | GAAGLAALDH1A1LMNA | |
| Bicarbonate SCHEMBL28147558 | 0.68 | THRB (0.35) | GAAEPHX1EPHX2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861126-A2 | TREATMENT OF PROTEIN DEGRADATION DISORDERS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006102557-A2 | TREATMENT OF PROTEIN DEGRADATION DISORDERS | THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2006-09-28 | — | — | WO | disclosed |