Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 4/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3556972 | 0.88 | REN (0.52) | RENALDH1A1KDM4EHPGD | |
| SCHEMBL3556975 | 0.88 | REN (0.52) | RENALDH1A1KDM4EHPGD | |
| SCHEMBL4974590 | 0.86 | REN (0.41) | RENALDH1A1KDM4ETSHRTDP1 | |
| SCHEMBL5593271 | 0.86 | REN (0.52) | RENCHRM3KDM4EMDM2 | |
| SCHEMBL3881752 | 0.85 | REN (0.52) | RENCHRM3KDM4EMDM2 | |
| SCHEMBL3880020 | 0.84 | REN (0.60) | RENCHRM3TSHRMDM2 | |
| SCHEMBL4969868 | 0.81 | REN (0.43) | RENALDH1A1KDM4ETSHRTDP1 | |
| SCHEMBL4972473 | 0.81 | REN (0.43) | RENALDH1A1KDM4ETSHRTDP1 | |
| SCHEMBL5593533 | 0.80 | REN (0.42) | RENCHRM3L3MBTL1MDM2HPGD | |
| SCHEMBL4972630 | 0.80 | REN (0.45) | RENALDH1A1KDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007117560-A2 | PIPERIDINE AND MORPHOLINE RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |