Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 9/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3881752 | 0.92 | REN (0.52) | RENCHRM3MDM2KDM4E | |
| SCHEMBL3880020 | 0.88 | REN (0.60) | RENCHRM3MDM2 | |
| SCHEMBL5616624 | 0.86 | REN (0.49) | RENCHRM3MDM2KDM4E | |
| SCHEMBL3571858 | 0.85 | REN (0.57) | REN | |
| SCHEMBL3571861 | 0.85 | REN (0.57) | REN | |
| SCHEMBL4973514 | 0.84 | REN (0.44) | RENCHRM3KDM4E | |
| SCHEMBL5593533 | 0.83 | REN (0.42) | RENCHRM3MDM2 | |
| SCHEMBL14403661 | 0.80 | REN (0.46) | RENKDM4E | |
| SCHEMBL4971018 | 0.79 | REN (0.46) | RENKDM4E | |
| SCHEMBL3569058 | 0.78 | REN (0.59) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007117560-A2 | PIPERIDINE AND MORPHOLINE RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |