Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | P2RY12 | Q9H244 | 14/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5592086 | 0.89 | REN (0.48) | RENLMNA | |
| SCHEMBL3569483 | 0.89 | REN (0.47) | REN | |
| SCHEMBL12991819 | 0.89 | REN (0.47) | REN | |
| SCHEMBL3569485 | 0.89 | REN (0.47) | REN | |
| SCHEMBL4292328 | 0.83 | REN (0.52) | REN | |
| SCHEMBL4295728 | 0.83 | REN (0.52) | REN | |
| SCHEMBL4302202 | 0.83 | REN (0.52) | REN | |
| SCHEMBL4295733 | 0.83 | REN (0.52) | REN | |
| SCHEMBL4292326 | 0.83 | REN (0.52) | REN | |
| SCHEMBL4300864 | 0.82 | REN (0.68) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007117560-A2 | PIPERIDINE AND MORPHOLINE RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |