Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 9/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5619273 | 0.92 | NPC1 (0.46) | GRIA2KMT2ANPC1RAB9APOLB | |
| SCHEMBL5620626 | 0.91 | PARP10 (0.47) | GRIA2 | |
| SCHEMBL5619218 | 0.89 | GRIA2 (0.53) | GRIA2KMT2AMEN1 | |
| SCHEMBL5620058 | 0.89 | GRIA2 (0.41) | GRIA2KMT2AMEN1NPC1RAB9A | |
| SCHEMBL5621573 | 0.84 | GRIA2 (0.43) | GRIA2MAOBSMN1; SMN2ALDH1A1 | |
| SCHEMBL5620763 | 0.83 | GRIA2 (0.52) | GRIA2PPARG | |
| SCHEMBL5619342 | 0.81 | GRIA2 (0.40) | GRIA2KMT2AMEN1 | |
| SCHEMBL5619278 | 0.81 | GRIA2 (0.56) | GRIA2NPC1RAB9APOLBCYP2C9 | |
| SCHEMBL5620621 | 0.80 | GRIA2 (0.52) | GRIA2 | |
| SCHEMBL5621041 | 0.80 | GRIA2 (0.40) | GRIA2POLBSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253161-B2 | Benzothiazine and benzothiadiazine derivatives method for preparing same and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2007-08-07 | — | — | US | disclosed |
| US-20050124606-A1 | Novel benzothiazine and benzothiadiazine derivatives method for preparing same and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124606-A1 | Novel benzothiazine and benzothiadiazine derivatives method for preparing same and pharmaceutical compositions containing same | NR4A3, NR5A2, NR4A1 | GRIA2 537/4885KMT2A 1039/4885MEN1 2276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.