Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 7/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.37 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5484644 | 0.90 | GRIA2 (0.40) | GRIA2PGRPOLBPIP4K2APIP4K2B | |
| SCHEMBL5621042 | 0.89 | GRIA2 (0.53) | GRIA2PGRDRD2DRD4DRD3 | |
| SCHEMBL5620019 | 0.89 | GRIA2 (0.39) | GRIA2PGRALDH1A1LMNAPKM | |
| SCHEMBL5482709 | 0.80 | LTA4H (0.41) | GRIA2PGRGRIN1GRIN2BLMNA | |
| SCHEMBL5619273 | 0.80 | NPC1 (0.46) | GRIA2POLBALDH1A1 | |
| SCHEMBL5619210 | 0.80 | GRIA2 (0.43) | GRIA2POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL5484649 | 0.79 | GRIA2 (0.51) | GRIA2PGR | |
| SCHEMBL5620626 | 0.79 | PARP10 (0.47) | GRIA2BTK | |
| SCHEMBL5620012 | 0.78 | GRIA2 (0.52) | GRIA2 | |
| SCHEMBL5619342 | 0.78 | GRIA2 (0.40) | GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253161-B2 | Benzothiazine and benzothiadiazine derivatives method for preparing same and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2007-08-07 | — | — | US | disclosed |
| US-20050124606-A1 | Novel benzothiazine and benzothiadiazine derivatives method for preparing same and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124606-A1 | Novel benzothiazine and benzothiadiazine derivatives method for preparing same and pharmaceutical compositions containing same | NR4A3, NR5A2, NR4A1 | GRIA2 537/4885PGR 589/4885POLB 3574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.