Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 2/20 | 0.31 |
| ▸ | ABL1 | P00519 | 3/20 | 0.31 |
| ▸ | RAF1 | P04049 | 3/20 | 0.31 |
| ▸ | LYN | P07948 | 3/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.31 |
| ▸ | SRC | P12931 | 2/20 | 0.31 |
| ▸ | EGFR | P00533 | 2/20 | 0.30 |
| ▸ | BRAF | P15056 | 2/20 | 0.30 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.30 |
| ▸ | EPHA3 | P29320 | 2/20 | 0.30 |
| ▸ | CIT | O14578 | 1/20 | 0.30 |
| ▸ | MUSK | O15146 | 1/20 | 0.30 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.30 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.30 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.30 |
| ▸ | STK10 | O94804 | 1/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14459367 | 0.88 | GCK (0.33) | MAPK14GRM5 | |
| SCHEMBL5619598 | 0.74 | GSK3A (0.41) | MAPK14GRM5GSK3AABL1RAF1 | |
| SCHEMBL5619805 | 0.73 | MAPK14 (0.43) | MAPK14GSK3AABL1RAF1LYN | |
| SCHEMBL5379421 | 0.71 | MAPK14 (0.62) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL6165074 | 0.66 | MAPK14 (0.44) | MAPK14GRM5RAF1 | |
| SCHEMBL5618849 | 0.65 | MAPK14 (0.38) | MAPK14GRM5GSK3AABL1RAF1 | |
| SCHEMBL7707024 | 0.65 | MAPK14 (0.39) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL297067 | 0.64 | MAPK14 (0.55) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL6574700 | 0.63 | MAPK14 (0.36) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL6163971 | 0.63 | MAPK14 (0.51) | MAPK14GRM5RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241758-B2 | Compounds useful as anti-inflammatory agents | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2007-07-10 | — | — | US | disclosed |
| US-6492393-B1 | SUCH AS 1-(5-TERT-BUTYL-2-METHOXYPHENYL)-3-(4-(2-METHOXY-PYRIDIN-4YL-OXY)-NAPHTHALEN-1-YL)-UREA; CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2002-12-10 | — | — | US | disclosed |