⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7287866 | 0.75 | GNAO1 (0.34) | — | |
| SCHEMBL150994 | 0.63 | — | — | |
| SCHEMBL9059716 | 0.61 | — | — | |
| SCHEMBL9059234 | 0.54 | — | — | |
| SCHEMBL9059876 | 0.53 | — | — | |
| SCHEMBL42921 | 0.52 | — | — | |
| SCHEMBL262312 | 0.48 | — | — | |
| SCHEMBL577415 | 0.48 | CHRNA7 (0.48) | — | |
| SCHEMBL577052 | 0.48 | CHRNA7 (0.48) | — | |
| SCHEMBL6657817 | 0.48 | CHRNA7 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7244738-B2 | Arylamine-substituted quinazolinone compounds useful as alpha 1A/B adrenergic receptor antagonists | ROCHE PALO ALTO LLC (US) | 2007-07-17 | — | — | US | claimed |
| US-20050038016-A1 | Arylamine-substituted quinazolinone compounds useful as alpha 1A/B adrenergic receptor antagonists | ROCHE PALO ALTO LLC | 2005-02-17 | — | — | US | claimed |
| US-RE33907-E | Anti-spasmodic agents having a heterocyclic ring | UNITED PHARMACEUTICALS, INC. (US) | 1992-04-28 | — | — | US | claimed |
| US-4857535-A | THIOESTERS | UNITED PHARMACEUTICALS (US) | 1989-08-15 | — | — | US | claimed |
| EP-0278158-A2 | Renin inhibitors containing phenylalanyl-histidine replacements | MERCK & CO. INC. (US) | 1988-08-17 | — | — | EP | claimed |
| US-4721783-A | SMOOTH MUSCLES | UNITED PHARMACEUTICALS, INC. (US) | 1988-01-26 | — | — | US | claimed |
| EP-0089041-B1 | USE OF A NEGATIVE ACTING PHOTOPOLYMERIZABLE ELEMENT AS A SOLDER MASK | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1987-11-25 | — | — | EP | claimed |
| EP-0089041-A1 | Use of a negative acting photopolymerizable element as a solder mask | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1983-09-21 | — | — | EP | claimed |
| US-20070265446-A1 | Arylamine-substituted quinazolinone compounds useful as alpha 1A/B adrenergic receptor antagonists | CONNOLLY TERRENCE J | 2007-11-15 | — | — | US | disclosed |
| US-7244738-B2 | Arylamine-substituted quinazolinone compounds useful as alpha 1A/B adrenergic receptor antagonists | ROCHE PALO ALTO LLC (US) | 2007-07-17 | — | — | US | disclosed |
| EP-1644369-A2 | ARYLAMINE-SUBSTITUTED QUINAZOLINONE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-04-12 | — | — | EP | disclosed |
| US-20050038016-A1 | Arylamine-substituted quinazolinone compounds useful as alpha 1A/B adrenergic receptor antagonists | ROCHE PALO ALTO LLC | 2005-02-17 | — | — | US | disclosed |
| WO-2005005395-A2 | ARYLAMINE-SUBSTITUTED QUINAZOLINONE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-01-20 | — | — | WO | disclosed |
| US-5684029-A | HYPOTENSIVE AGENTS | KARL THOMAE GMBH (DE) | 1997-11-04 | — | — | US | disclosed |
| US-4857535-A | THIOESTERS | UNITED PHARMACEUTICALS (US) | 1989-08-15 | — | — | US | disclosed |
| EP-0278158-A2 | Renin inhibitors containing phenylalanyl-histidine replacements | MERCK & CO. INC. (US) | 1988-08-17 | — | — | EP | disclosed |
| US-4721783-A | SMOOTH MUSCLES | UNITED PHARMACEUTICALS, INC. (US) | 1988-01-26 | — | — | US | disclosed |
| US-4497889-A | Release compound in negative acting photopolymerizable element | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-02-05 | — | — | US | disclosed |
| US-4476135-A | Amino-2,1,3-benzothiadiazole and -benzoxadiazole derivatives, their preparation and pharmaceutical compositions containing them | SANDOZ LTD. (CH) | 1984-10-09 | — | — | US | disclosed |
| EP-0089041-A1 | Use of a negative acting photopolymerizable element as a solder mask | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1983-09-21 | — | — | EP | disclosed |