Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | CASP1 | P29466 | 2/20 | 0.55 |
| ▸ | CASP7 | P55210 | 1/20 | 0.55 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28864707 | 0.86 | NPC1 (0.60) | HTTCYP1A2CYP2C19ALDH1A1MEN1 | |
| SCHEMBL29955934 | 0.82 | ALDH1A1 (0.53) | HTTCYP1A2CYP2C19ALDH1A1MEN1 | |
| SCHEMBL401692 | 0.82 | ALDH1A1 (0.53) | HTTCYP1A2CYP2C19ALDH1A1MEN1 | |
| SCHEMBL27572181 | 0.82 | ALDH1A1 (0.53) | HTTCYP1A2CYP2C19ALDH1A1MEN1 | |
| SCHEMBL8152450 | 0.82 | ALDH1A1 (0.53) | HTTCYP1A2CYP2C19ALDH1A1MEN1 | |
| SCHEMBL6630673 | 0.82 | ALDH1A1 (0.53) | HTTCYP1A2CYP2C19ALDH1A1MEN1 | |
| SCHEMBL24817285 | 0.82 | ALDH1A1 (0.49) | HTTCYP1A2CYP2C19ALDH1A1MEN1 | |
| SCHEMBL9970465 | 0.81 | NPC1 (0.54) | HTTCYP1A2CYP2C19ALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL27466069 | 0.81 | ALDH1A1 (0.52) | HTTCYP1A2CYP2C19ALDH1A1MEN1 | |
| SCHEMBL6656717 | 0.79 | ALDH1A1 (0.50) | HTTCYP1A2CYP2C19ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070173525-A1 | Tyrosine kinase inhibitors | MERCK SHARP & DOHME CORP. | 2007-07-26 | — | — | US | disclosed |
| EP-1496897-A4 | TYROSINE KINASE INHIBITORS | MERCK & CO INC (US) | 2006-05-10 | — | — | EP | disclosed |
| US-20050239815-A1 | Tyrosine kinase inhibitors | KIM ANNETTE J | 2005-10-27 | — | — | US | disclosed |
| EP-1496897-A1 | TYROSINE KINASE INHIBITORS | Merck & Co., Inc. (US) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003086395-A1 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173525-A1 | Tyrosine kinase inhibitors | ABL1, JAK2, ERBB2 | HTT 2910/4885CYP1A2 2062/4885CYP2C19 1764/4885 |
| US-20050239815-A1 | Tyrosine kinase inhibitors | ABL1, JAK2, ERBB2 | HTT 2910/4885CYP1A2 2062/4885CYP2C19 1764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.