Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5619852 | 0.91 | S100A4 (0.36) | S100A4DRD2OPRM1DRD3OPRD1 | |
| SCHEMBL5620240 | 0.85 | ESR1 (0.43) | DRD2OPRM1DRD3OPRD1OPRK1 | |
| SCHEMBL5619057 | 0.82 | S100A4 (0.37) | S100A4KDM4EALDH1A1FFAR4ESR1 | |
| SCHEMBL5619055 | 0.76 | ESR1 (0.43) | DRD2OPRM1DRD3OPRD1OPRK1 | |
| SCHEMBL5619855 | 0.71 | ESR1 (0.43) | DRD2OPRM1DRD3OPRD1OPRK1 | |
| SCHEMBL5620664 | 0.67 | ESR1 (0.47) | DRD2OPRM1DRD3OPRD1OPRK1 | |
| SCHEMBL18356536 | 0.65 | CYP2A6 (0.56) | PIK3CDCDC7RIPK1HSD17B1HSD17B2 | |
| SCHEMBL14818792 | 0.65 | ALDH1A1 (0.55) | DRD2OPRM1DRD3OPRD1OPRK1 | |
| SCHEMBL14382436 | 0.65 | ESR1 (0.66) | DRD2OPRM1DRD3OPRD1OPRK1 | |
| SCHEMBL14382434 | 0.64 | ESR1 (0.69) | ESR1ESR2HSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7276523-B2 | Aminopyridine derivatives as estrogen receptor modulators | SMITHKLINE BEECHAM CORPORATION (US) | 2007-10-02 | — | — | US | claimed |
| US-20040152688-A1 | Aminopyridine derivatives as estrogen receptor modulators | SMITHKLINE BEECHAM CORPORATION | 2004-08-05 | — | — | US | claimed |
| US-7276523-B2 | Aminopyridine derivatives as estrogen receptor modulators | SMITHKLINE BEECHAM CORPORATION (US) | 2007-10-02 | — | — | US | disclosed |
| US-20040152688-A1 | Aminopyridine derivatives as estrogen receptor modulators | SMITHKLINE BEECHAM CORPORATION | 2004-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040152688-A1 | Aminopyridine derivatives as estrogen receptor modulators | ESR2, GPER1, ESR1 | S100A4 1121/4885DRD2 512/4885OPRM1 153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.