Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 5/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.38 |
| ▸ | WEE1 | P30291 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5307617 | 1.00 | KDM4E (0.47) | KDM4EMAPK1MEN1APAF1ALDH1A1 | |
| SCHEMBL5621308 | 0.87 | KDM4E (0.51) | KDM4EALDH1A1MAPTKMT2AHSD17B10 | |
| SCHEMBL5307614 | 0.87 | KDM4E (0.51) | KDM4EALDH1A1MAPTKMT2AHSD17B10 | |
| SCHEMBL14439794 | 0.77 | PTPN1 (0.58) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL14303335 | 0.77 | PTPN1 (0.58) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL6887204 | 0.74 | SCN2A (0.47) | KDM4EMAPK1MEN1APAF1ALDH1A1 | |
| SCHEMBL6887052 | 0.74 | SCN2A (0.47) | KDM4EMAPK1MEN1APAF1ALDH1A1 | |
| SCHEMBL2977660 | 0.70 | FAAH (0.57) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL5621234 | 0.70 | KDM4E (0.39) | KDM4EALDH1A1TP53DYRK3CLK2 | |
| SCHEMBL30800857 | 0.70 | MAPT (0.55) | KDM4EMAPK1MEN1APAF1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256287-B2 | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2007-08-14 | — | — | US | disclosed |
| US-20040116466-A1 | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation | AVANIR PHARMACEUTICALS | 2004-06-17 | — | — | US | disclosed |