Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.50 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.50 |
| ▸ | NR2E3 | Q9Y5X4 | 3/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.45 |
| ▸ | WNT1 | P04628 | 2/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5621308 | 1.00 | KDM4E (0.51) | KDM4ETP53PTPN1PTPN2NR2E3 | |
| SCHEMBL14303335 | 0.93 | PTPN1 (0.58) | KDM4ETP53PTPN1PTPN2NR2E3 | |
| SCHEMBL14439794 | 0.93 | PTPN1 (0.58) | KDM4ETP53PTPN1PTPN2NR2E3 | |
| SCHEMBL5621310 | 0.87 | KDM4E (0.47) | KDM4ETP53TRPV1ALDH1A1MAPT | |
| SCHEMBL5307617 | 0.87 | KDM4E (0.47) | KDM4ETP53TRPV1ALDH1A1MAPT | |
| SCHEMBL6887046 | 0.79 | PTPN1 (0.54) | KDM4ETP53PTPN1PTPN2NR2E3 | |
| SCHEMBL6887198 | 0.79 | PTPN1 (0.54) | KDM4ETP53PTPN1PTPN2NR2E3 | |
| SCHEMBL6028361 | 0.79 | PTPN1 (0.54) | KDM4ETP53PTPN1PTPN2NR2E3 | |
| SCHEMBL14439813 | 0.77 | NR2E3 (0.64) | KDM4ETP53PTPN1PTPN2NR2E3 | |
| SCHEMBL14305024 | 0.77 | NR2E3 (0.64) | KDM4ETP53PTPN1PTPN2NR2E3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256287-B2 | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2007-08-14 | — | — | US | disclosed |
| EP-1546157-A4 | PHENYL-AZA-BENZIMIDAZOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION | AVANIR PHARMACEUTICALS (US) | 2007-02-28 | — | — | EP | disclosed |
| CN-1694889-A | Phenyl-aza-benzimidazole compounds for modulating ige and inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2005-11-09 | — | — | CN | disclosed |
| EP-1546157-A2 | PHENYL-AZA-BENZIMIDAZOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION | Avanir Pharmaceuticals (US) | 2005-06-29 | — | — | EP | disclosed |
| US-20040116466-A1 | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation | AVANIR PHARMACEUTICALS | 2004-06-17 | — | — | US | disclosed |
| WO-2004024897-A2 | PHENYL-AZA-BENZIMIDAZOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION | AVANIR PHARMACEUTICALS (US) | 2004-03-25 | — | — | WO | disclosed |