Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 4/20 | 0.60 |
| ▸ | TTR | P02766 | 3/20 | 0.60 |
| ▸ | ESR1 | P03372 | 2/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 7/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.55 |
| ▸ | ALOX15B | O15296 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SYNJ2 | O15056 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.36 |
| ▸ | SHBG | P04278 | 1/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.36 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6944038 | 0.85 | ESR1 (0.63) | ESR2TTRESR1ALOX12ALOX15 | |
| SCHEMBL3954415 | 0.85 | ESR1 (0.63) | ESR2TTRESR1ALOX12ALOX15 | |
| SCHEMBL29391808 | 0.85 | ESR1 (0.63) | ESR2TTRESR1ALOX12ALOX15 | |
| Hydrochloric Acid SCHEMBL4294837 | 0.84 | ESR1 (0.61) | ESR2TTRESR1ALOX12ALOX15 | |
| SCHEMBL31545141 | 0.82 | ESR2 (0.60) | ESR2TTRESR1ALOX12ALOX15 | |
| SCHEMBL31545620 | 0.77 | ESR1 (0.53) | ESR2TTRESR1ALOX12ALOX15 | |
| SCHEMBL13923917 | 0.75 | ALOX15 (0.53) | ESR2TTRESR1ALOX12ALOX15 | |
| Aus-131 SCHEMBL2002128 | 0.75 | ESR2 (1.00) | ESR2TTRESR1ALOX12ALOX15 | |
| Aus-131 SCHEMBL677723 | 0.75 | ESR2 (1.00) | ESR2TTRESR1ALOX12ALOX15 | |
| Aus-131 SCHEMBL43648 | 0.75 | ESR2 (1.00) | ESR2TTRESR1ALOX12ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7226945-B2 | Estrogen receptor-β ligands | ASTRAZENECA AB (SE) | 2007-06-05 | — | — | US | disclosed |
| US-7226945-B2 | Estrogen receptor-β ligands | ASTRAZENECA AB (SE) | 2007-06-05 | — | — | US | disclosed |
| US-7226945-B2 | Estrogen receptor-β ligands | ASTRAZENECA AB (SE) | 2007-06-05 | — | — | US | disclosed |
| US-20050043350-A9 | Estrogen Receptor-beta ligands | ASTRAZENECA AB (SE) | 2005-02-24 | — | — | US | disclosed |
| US-20040039015-A1 | Estrogen Receptor-beta ligands | BARLAAM BERNARD (FR) | 2004-02-26 | — | — | US | disclosed |
| EP-1326593-A1 | ESTROGEN RECEPTOR-$g(b) LIGANDS | AstraZeneca AB (SE) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002030407-A1 | ESTROGEN RECEPTOR-β LIGANDS | ASTRAZENECA AB (SE) | 2002-04-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043350-A9 | Estrogen Receptor-beta ligands | ESR2, GPER1, ESR1 | ESR2 1/4885TTR 3575/4885ESR1 3/4885 |
| US-20040039015-A1 | Estrogen Receptor-beta ligands | ESR2, GPER1, ESRRG | ESR2 1/4885TTR 2703/4885ESR1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.