Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 3/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6023784 | 0.87 | ADAM10 (0.52) | ADAM10MMP2MMP3MMP9ATM | |
| SCHEMBL6024795 | 0.84 | ADAM10 (0.33) | ADAM10MMP2MMP3MMP9ATM | |
| SCHEMBL6024829 | 0.79 | ADAM10 (0.38) | ADAM10MMP2MMP3 | |
| SCHEMBL5039259 | 0.78 | ADAM10 (0.64) | ADAM10MMP2MMP3MMP9 | |
| SCHEMBL5038238 | 0.78 | ADAM10 (0.64) | ADAM10MMP2MMP3MMP9 | |
| SCHEMBL6024352 | 0.72 | ADAM10 (0.43) | ADAM10MMP2MMP3MMP9ATM | |
| SCHEMBL5621610 | 0.72 | ADAM10 (0.43) | ADAM10MMP2MMP3MMP9ATM | |
| SCHEMBL5035330 | 0.68 | ADAM10 (0.53) | ADAM10MMP2MMP3MMP9 | |
| SCHEMBL5040167 | 0.67 | ADAM10 (0.50) | ADAM10MMP2MMP3MMP9 | |
| SCHEMBL5042911 | 0.66 | ADAM10 (0.63) | ADAM10MMP2MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007509075-A | — | — | 2007-04-12 | — | — | JP | claimed |
| EP-1678167-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | Incyte Corporation (US) | 2006-07-12 | — | — | EP | claimed |
| WO-2005037826-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | INCYTE CORPORATION (US) | 2005-04-28 | — | — | WO | claimed |
| EP-1678167-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | Incyte Corporation (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005037826-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | INCYTE CORPORATION (US) | 2005-04-28 | — | — | WO | disclosed |