Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ADH1A | P07327 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | ABL2 | P42684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GPR183 | P32249 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5623910 | 1.00 | ALDH1A1 (0.41) | ALDH1A1GAALMNAHPGDADH1A | |
| SCHEMBL21366179 | 0.87 | ALDH1A1 (0.44) | ALDH1A1GAALMNAHPGDADH1A | |
| SCHEMBL14499189 | 0.85 | ALDH1A1 (0.47) | ALDH1A1GAALMNAHPGDADH1A | |
| SCHEMBL6204431 | 0.84 | ALDH1A1 (0.40) | ALDH1A1GAALMNAHPGDADH1A | |
| SCHEMBL6204423 | 0.84 | ALDH1A1 (0.40) | ALDH1A1GAALMNAHPGDADH1A | |
| SCHEMBL74903 | 0.84 | ALDH1A1 (0.46) | ALDH1A1GAALMNAHPGDADH1A | |
| SCHEMBL26322204 | 0.84 | ALDH1A1 (0.46) | ALDH1A1GAALMNAHPGDADH1A | |
| SCHEMBL74904 | 0.84 | ALDH1A1 (0.46) | ALDH1A1GAALMNAHPGDADH1A | |
| SCHEMBL18378477 | 0.80 | ALDH1A1 (0.42) | ALDH1A1GAALMNAHPGDADH1A | |
| SCHEMBL18308252 | 0.80 | ALDH1A1 (0.42) | ALDH1A1GAALMNAHPGDADH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235578-B2 | Processes for preparing 3-substituted 1-(chloromethyl)-1,2-dihydro-3H-[ring fused indol-5-yl-(amine-derived)] compounds and analogues thereof, and to products obtained therefrom | AUCKLAND UNISERVICES LIMITED (NZ) | 2007-06-26 | — | — | US | claimed |
| US-20050148651-A1 | Processes for preparing 3-substituted 1-(chloromethyl)-1,2-dihydro-3h-[ring fused indol-5-yl-(amine- derived)] compounds and analogues thereof, and to products obtained therefrom | AUCKLAND UNISERVICES LIMITED (NZ) | 2005-07-07 | — | — | US | claimed |
| WO-2003097635-A1 | PROCESSES FOR PREPARING 3-SUBSTITUTED 1-(CHLOROMETHYL)-1,2-DIHYDRO-3H-[RING FUSED INDOL-5-YL(AMINE-DERIVED)] COMPOUNDS AND ANALOGUES THEREOF, AND TO PRODUCTS OBTAINED THEREFROM | AUCKLAND UNISERVICES LIMITED (NZ) | 2003-11-27 | — | — | WO | claimed |
| US-7235578-B2 | Processes for preparing 3-substituted 1-(chloromethyl)-1,2-dihydro-3H-[ring fused indol-5-yl-(amine-derived)] compounds and analogues thereof, and to products obtained therefrom | AUCKLAND UNISERVICES LIMITED (NZ) | 2007-06-26 | — | — | US | disclosed |
| US-20050148651-A1 | Processes for preparing 3-substituted 1-(chloromethyl)-1,2-dihydro-3h-[ring fused indol-5-yl-(amine- derived)] compounds and analogues thereof, and to products obtained therefrom | AUCKLAND UNISERVICES LIMITED (NZ) | 2005-07-07 | — | — | US | disclosed |
| WO-2003097635-A1 | PROCESSES FOR PREPARING 3-SUBSTITUTED 1-(CHLOROMETHYL)-1,2-DIHYDRO-3H-[RING FUSED INDOL-5-YL(AMINE-DERIVED)] COMPOUNDS AND ANALOGUES THEREOF, AND TO PRODUCTS OBTAINED THEREFROM | AUCKLAND UNISERVICES LIMITED (NZ) | 2003-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050148651-A1 | Processes for preparing 3-substituted 1-(chloromethyl)-1,2-dihydro-3h-[ring fused indol-5-yl-(amine- derived)] compounds and analogues thereof, and to products obtained therefrom | CBR3, ANPEP, CBR1 | ALDH1A1 437/4885GAA 641/4885LMNA 4679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.