Sugi Predict

Sugi Predict / Compounds / SCHEMBL5624684

SCHEMBL5624684

SCHEMBL5624684

O=c1[nH]c(C(F)(F)F)nc2ccc(S(=O)(=O)O)cc12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PKM P14618 1/20 0.56
▸ ALDH1A1 P00352 4/20 0.53
▸ KDM4E B2RXH2 3/20 0.53
▸ HPGD P15428 2/20 0.53
▸ HSD17B10 Q99714 2/20 0.53
▸ KDM5A P29375 1/20 0.49
▸ KDM4C Q9H3R0 1/20 0.49
▸ SMN1; SMN2 Q16637 2/20 0.45
▸ LMNA P02545 2/20 0.43
▸ PARP1 P09874 1/20 0.43
▸ HDAC6 Q9UBN7 1/20 0.43
▸ HCAR2 Q8TDS4 1/20 0.43
▸ PARG Q86W56 4/20 0.40
▸ ACP1 P24666 1/20 0.40
▸ MEN1 O00255 1/20 0.39
▸ THRB P10828 1/20 0.39
▸ APEX1 P27695 1/20 0.39
▸ RECQL P46063 1/20 0.39
▸ BLM P54132 1/20 0.39
▸ KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5624626 0.86 PKM (0.56) PKMALDH1A1KDM4EHPGDHSD17B10
SCHEMBL5624928 0.83 PKM (0.52) PKMALDH1A1KDM4EHPGDHSD17B10
SCHEMBL6373949 0.77 SMN1; SMN2 (0.69) PKMALDH1A1KDM4EHPGDHSD17B10
SCHEMBL7441265 0.77 PKM (0.62) PKMALDH1A1KDM4EHPGDHSD17B10
SCHEMBL6373754 0.77 PKM (0.62) PKMALDH1A1KDM4EHPGDHSD17B10
SCHEMBL6373947 0.77 PKM (0.62) PKMALDH1A1KDM4EHPGDHSD17B10
SCHEMBL5310066 0.77 PKM (0.62) PKMALDH1A1KDM4EHPGDHSD17B10
SCHEMBL5625061 0.76 TDP1 (0.51) PKMALDH1A1KDM4EHPGDSMN1; SMN2
SCHEMBL6373903 0.76 PKM (0.57) PKMALDH1A1KDM4EHPGDHSD17B10
SCHEMBL6372270 0.75 PKM (0.56) PKMALDH1A1KDM4EHPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040043987-A1 Novel compounds and their use as positive AMPA receptor modulators NEUROSEARCH A/S. 2004-03-04 — — US claimed
EP-1071426-A2 NOVEL COMPOUNDS AND THEIR USE AS POSITIVE AMPA RECEPTOR MODULATORS NEUROSEARCH A/S (DK) 2001-01-31 — — EP claimed
WO-1999042456-A2 NOVEL COMPOUNDS AND THEIR USE AS POSITIVE AMPA RECEPTOR MODULATORS NEUROSEARCH A/S (DK) 1999-08-26 — — WO claimed
US-7235548-B2 Compounds and their use as positive AMPA receptor modulators NEUROSEARCH A/S (DK) 2007-06-26 — — US disclosed
US-6943159-B1 Compounds and their use as positive AMPA receptor modulators NEUROSEARCH A/S (DK) 2005-09-13 — — US disclosed
US-20040043987-A1 Novel compounds and their use as positive AMPA receptor modulators NEUROSEARCH A/S. 2004-03-04 — — US disclosed
EP-1071426-A2 NOVEL COMPOUNDS AND THEIR USE AS POSITIVE AMPA RECEPTOR MODULATORS NEUROSEARCH A/S (DK) 2001-01-31 — — EP disclosed
WO-1999042456-A2 NOVEL COMPOUNDS AND THEIR USE AS POSITIVE AMPA RECEPTOR MODULATORS NEUROSEARCH A/S (DK) 1999-08-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040043987-A1 Novel compounds and their use as positive AMPA receptor modulators GRIK4, GRIA4, GRM2 PKM 3507/4885ALDH1A1 3816/4885KDM4E 1058/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.