Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 7/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 6/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL150047 | 0.94 | HTT (0.70) | HTTCYP3A4LMNAMAPK1TAAR1 | |
| SCHEMBL29612168 | 0.94 | HTT (0.70) | HTTCYP3A4LMNAMAPK1TAAR1 | |
| SCHEMBL21914 | 0.82 | HTT (0.62) | HTTCYP3A4LMNAMAPK1CYP1A2 | |
| SCHEMBL29380490 | 0.82 | HTT (0.62) | HTTCYP3A4LMNAMAPK1CYP1A2 | |
| SCHEMBL6141606 | 0.81 | CYP3A4 (0.68) | HTTCYP3A4LMNAMAPK1TAAR1 | |
| SCHEMBL29524840 | 0.81 | CYP3A4 (0.68) | HTTCYP3A4LMNAMAPK1TAAR1 | |
| SCHEMBL6243538 | 0.81 | HTT (0.60) | HTTCYP3A4LMNAMAPK1CYP1A2 | |
| SCHEMBL10918760 | 0.81 | HTT (0.60) | HTTCYP3A4LMNAMAPK1CYP1A2 | |
| SCHEMBL16145699 | 0.80 | HTT (0.65) | HTTCYP3A4LMNAMAPK1TAAR1 | |
| SCHEMBL10344772 | 0.79 | HTT (0.60) | HTTCYP3A4LMNAMAPK1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1791567-A2 | CHEMICALLY MODIFIED OLIGONUCLEOTIDES | Alnylam Pharmaceuticals Inc. (US) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006020768-A2 | CHEMICALLY MODIFIED OLIGONUCLEOTIDES | ALNYLAM PHARMACEUTICALS, INC. (US) | 2006-02-23 | — | — | WO | disclosed |