Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR9 | P51686 | 6/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.48 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29087421 | 0.83 | KMT2A (0.64) | CCR9TSHRMEN1KMT2AFFAR4 | |
| SCHEMBL5069496 | 0.81 | CCR9 (0.58) | CCR9TSHRKDM4EPTK2BCCR2 | |
| SCHEMBL28301 | 0.81 | CCR9 (0.74) | CCR9KMT2ACCR2 | |
| SCHEMBL12407078 | 0.79 | FFAR4 (0.55) | CCR9TSHRKDM4EMEN1KMT2A | |
| SCHEMBL15821484 | 0.77 | ALDH1A1 (0.59) | CCR9TSHRKDM4EMEN1KMT2A | |
| SCHEMBL20686121 | 0.76 | ELANE (0.55) | CCR9KDM4EKMT2AFFAR4HDAC3 | |
| SCHEMBL29561208 | 0.75 | MAPT (0.57) | CCR9FFAR4HDAC3HDAC4HDAC1 | |
| SCHEMBL3980968 | 0.74 | MEN1 (0.67) | TSHRMEN1KMT2A | |
| SCHEMBL3048026 | 0.74 | CCR1 (0.51) | CCR2 | |
| SCHEMBL14458120 | 0.74 | ELANE (0.56) | CCR9KDM4EFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7227035-B2 | Bis-aryl sulfonamides | CHEMOCENTRYX (US) | 2007-06-05 | — | — | US | claimed |