Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 3/20 | 0.42 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 7/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | CPT2 | P23786 | 2/20 | 0.36 |
| ▸ | CPT1A | P50416 | 2/20 | 0.36 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4559981 | 0.97 | SCD (0.45) | SCDSCD5USP30HRH3GRM5 | |
| SCHEMBL4559982 | 0.97 | SCD (0.45) | SCDSCD5USP30HRH3GRM5 | |
| SCHEMBL5627991 | 0.92 | CHRNB2 (0.41) | SCDSCD5USP30HRH3CPT2 | |
| SCHEMBL5658775 | 0.89 | SCD (0.44) | SCDSCD5USP30CYP3A4CYP2C9 | |
| SCHEMBL5658783 | 0.89 | SCD (0.44) | SCDSCD5USP30CYP3A4CYP2C9 | |
| SCHEMBL4347350 | 0.89 | USP30 (0.44) | SCDSCD5USP30GRM5ALOX12 | |
| SCHEMBL4347341 | 0.89 | USP30 (0.44) | SCDSCD5USP30GRM5ALOX12 | |
| SCHEMBL2896421 | 0.88 | SCD5 (0.44) | SCDSCD5USP30HRH3CYP3A4 | |
| SCHEMBL2896412 | 0.88 | SCD5 (0.44) | SCDSCD5USP30HRH3CYP3A4 | |
| SCHEMBL5450497 | 0.87 | KCNH2 (0.42) | GRM5HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070259916-A1 | mGluR5 modulators II | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | disclosed |
| US-20070259916-A1 | mGluR5 modulators II | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | disclosed |
| US-20070259916-A1 | mGluR5 modulators II | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259916-A1 | mGluR5 modulators II | GRM5, GRM2, GRIK5 | SCD 1757/4885SCD5 378/4885USP30 3230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.