Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL563133 | 1.00 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2TDP1L3MBTL1MAPK1 | |
| SCHEMBL562931 | 0.78 | APEX1 (0.38) | ALDH1A1SMN1; SMN2L3MBTL1TP53 | |
| SCHEMBL10415272 | 0.76 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL10033422 | 0.74 | APEX1 (0.37) | L3MBTL1TP53 | |
| SCHEMBL21704253 | 0.74 | HPGD (0.60) | ALDH1A1SMN1; SMN2L3MBTL1HPGDGLA | |
| SCHEMBL20722377 | 0.74 | HPGD (0.60) | ALDH1A1SMN1; SMN2L3MBTL1HPGDGLA | |
| SCHEMBL6646350 | 0.72 | DPP4 (0.52) | ALDH1A1SMN1; SMN2L3MBTL1MAPK1ATM | |
| SCHEMBL6648103 | 0.72 | DPP4 (0.52) | ALDH1A1SMN1; SMN2L3MBTL1MAPK1ATM | |
| SCHEMBL1011103 | 0.72 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2TDP1L3MBTL1MAPK1 | |
| SCHEMBL563134 | 0.71 | HPGD (0.41) | ALDH1A1TDP1HPGDELANECTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420818-B2 | Process for the preparation of pyrido[2,1-a] isoquinoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2013-04-16 | — | — | US | disclosed |
| EP-2234997-B1 | PROCESS FOR THE PREPARATION OF PYRIDO[2,1-A]ISOQUINOLINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-09-05 | — | — | EP | disclosed |
| US-20120035368-A1 | PROCESS FOR THE PREPARATION OF PYRIDO[2,1-a] ISOQUINOLINE DERIVATIVES | ABRECHT STEFAN (CH) | 2012-02-09 | — | — | US | disclosed |
| US-20090163718-A1 | PROCESS FOR THE PREPARATION OF PYRIDO[2,1-a] ISOQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163718-A1 | PROCESS FOR THE PREPARATION OF PYRIDO[2,1-a] ISOQUINOLINE DERIVATIVES | DPP4, DPP7, DPP3 | ALDH1A1 62/4885SMN1; SMN2 2704/4885TDP1 704/4885 |
| US-20120035368-A1 | PROCESS FOR THE PREPARATION OF PYRIDO[2,1-a] ISOQUINOLINE DERIVATIVES | DPP4, DPP7, DPP3 | ALDH1A1 62/4885SMN1; SMN2 2704/4885TDP1 704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.