SCHEMBL563223

SCHEMBL563223

Oc1c(Cl)cc(Cl)cc1-n1nc2ccccc2n1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.71
RAB9A P51151 3/20 0.71
LMNA P02545 4/20 0.46
POLB P06746 4/20 0.44
ALDH1A1 P00352 7/20 0.43
CYP3A4 P08684 2/20 0.43
TSHR P16473 2/20 0.43
RECQL P46063 2/20 0.43
HSD17B10 Q99714 2/20 0.43
HTT P42858 2/20 0.41
KDM4E B2RXH2 5/20 0.38
HPGD P15428 3/20 0.38
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
GFER P55789 1/20 0.38
HSP90AA1 P07900 1/20 0.37
ALPL P05186 1/20 0.36
MAPT P10636 4/20 0.36
SMN1; SMN2 Q16637 3/20 0.36
GAA P10253 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10598824 0.83 NPC1 (1.00) NPC1RAB9ALMNAPOLBALDH1A1
SCHEMBL10596458 0.80 NPC1 (0.67) NPC1RAB9ALMNAPOLBALDH1A1
SCHEMBL9408769 0.80 NPC1 (0.51) NPC1RAB9ALMNAPOLBALDH1A1
SCHEMBL11410839 0.79 NPC1 (0.51) NPC1RAB9ALMNAPOLBALDH1A1
SCHEMBL11593965 0.79 NPC1 (0.46) NPC1RAB9ALMNAPOLBALDH1A1
SCHEMBL3582168 0.77 NPC1 (0.65) NPC1RAB9ALMNAPOLBALDH1A1
SCHEMBL11616092 0.75 NPC1 (0.64) NPC1RAB9ALMNAPOLBALDH1A1
SCHEMBL11618064 0.75 NPC1 (0.53) NPC1RAB9ALMNAPOLBALDH1A1
SCHEMBL11615531 0.75 NPC1 (0.50) NPC1RAB9ALMNAPOLBALDH1A1
SCHEMBL29814234 0.75 NPC1 (0.57) NPC1RAB9ALMNAPOLBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4467061-A POLYOLEFIN BLENDS WITH BENZOTRIAZOLE COMPOUND, HINDERED AMINE, PHENYL BENZOATE OR NICKEL COMPLEX TONEN SEKIYU KAGAKU KABUSHIKI KAISHA (JP) 1984-08-21 US claimed
US-9375903-B2 Laminated polyester film and hardcoat film TORAY INDUSTRIES, INC. (JP) 2016-06-28 US disclosed
US-20160177130-A1 HYBRID POLYSILOXANE COATED ARMOR OR FIBER SUBSTRATES SAVAGE RYAN HALE (US) 2016-06-23 US disclosed
US-8877334-B2 Surface protection film KIMOTO CO., LTD. (JP) 2014-11-04 US disclosed
EP-2666633-A1 LAYERED POLYESTER FILM AND HARDCOAT FILM Toray Industries, Inc. (JP) 2013-11-27 EP disclosed
US-20130302582-A1 LAMINATED POLYESTER FILM AND HARDCOAT FILM TORAY INDUSTRIES, INC. (JP) 2013-11-14 US disclosed
EP-2063295-B1 Fluorescent retroreflective sheeting NIPPON CARBIDE KOGYO KK (JP) 2012-04-18 EP disclosed
US-20120034450-A1 SURFACE PROTECTION FILM KIMOTO CO., LTD. (JP) 2012-02-09 US disclosed
US-20100276073-A1 Surface Substrate Film for Motor Vehicle Brade Disc Antirust Film LINTEC CORPORATION 2010-11-04 US disclosed
EP-1748382-B1 Integrated circuit enclosed retroreflective product NIPPON CARBIDE KOGYO KK (JP) 2010-07-07 EP disclosed
US-4403053-A WITH 2-HYDROXYPHENYLBENZOTRIAZOLE AND BIS (DIALKYLPHENYL) PENTAERYTHRITOL DIPHOSPHITE BORG-WARNER CORPORATION (US) 1983-09-06 US disclosed
EP-0065574-A1 PHOTOSYNTHETIC BACTERIA CULTURE NIPPON CARBIDE KOGYO KABUSHIKI KAISHA (JP) 1982-12-01 EP disclosed
US-4251435-A FOR POLYOLEFINS THE B. F. GOODRICH COMPANY (US) 1981-02-17 US disclosed
US-4235043-A Method for cultivating algae and a covering material used therefor Nippon Carbide Kogyo Kabashiki Kaisha (JP) 1980-11-25 US disclosed
US-4206111-A 2-HYDROXYPHENYL-BENZOTRIAZOLES, DIALKYL PENTAERYTHRITOL, AND A PHENOLIC ESTER BORG-WARNER CORPORATION (US) 1980-06-03 US disclosed
US-4128559-A ANTIDEPRESSANT EASTMAN KODAK COMPANY (US) 1978-12-05 US disclosed
US-4041011-A FOR POLYMERS EASTMAN KODAK COMPANY (US) 1977-08-09 US disclosed
US-3936418-A Benzotriazole ortho-ester ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1976-02-03 US disclosed
US-3935164-A NICKEL 3,5-DI-TERT-ALKYL 4-HYDROXYBENZOATE, AND A BENZOPHENONE OR BENZOTRIAZOLE CIBA-GEIGY CORPORATION (US) 1976-01-27 US disclosed
US-3935163-A NICKEL BIS(3,5-DI-TERT-ALKYL-4-HYDROXY BENZOATE AND A BENZOPHENONE OR BENZOTRIAZOLE CIBA-GEIGY CORPORATION (US) 1976-01-27 US disclosed