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SCHEMBL5633552

SCHEMBL5633552

CCCCn1c(-c2c(C)cccc2C)nc(Cl)c1CN(C)C(CCC(C)C)c1ccc(OC(F)F)cc1

nearest known ligand 0.31

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ CASR P41180 2/20 0.31
▸ BACE1 P56817 2/20 0.31
▸ ALDH1A1 P00352 1/20 0.30
▸ HTT P42858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL650781 0.72 KMT2A (0.37) CASRALDH1A1
SCHEMBL1913031 0.70 TSHR (0.40) CASRALDH1A1HTT
SCHEMBL5928902 0.68 TLR8 (0.43) CASR
SCHEMBL1912873 0.68 CRHR1 (0.39) ALDH1A1
SCHEMBL5929077 0.67 TLR8 (0.42) —
SCHEMBL649555 0.66 SMN1; SMN2 (0.35) CASRALDH1A1
SCHEMBL648961 0.65 TLR7 (0.36) BACE1ALDH1A1HTT
SCHEMBL648619 0.65 AGTR1 (0.40) ALDH1A1HTT
SCHEMBL1912882 0.64 BCHE (0.39) ALDH1A1HTT
SCHEMBL648120 0.64 SMPD1 (0.38) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7186734-B2 Aryl imidazoles and related compounds as C5a receptor modulators NEUROGEN CORPORATION (US) 2007-03-06 — — US disclosed
US-7186734-B2 Aryl imidazoles and related compounds as C5a receptor modulators NEUROGEN CORPORATION (US) 2007-03-06 — — US disclosed
US-7186734-B2 Aryl imidazoles and related compounds as C5a receptor modulators NEUROGEN CORPORATION (US) 2007-03-06 — — US disclosed