Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5031084 | 0.97 | — | — | |
| Bromide SCHEMBL5633596 | 0.94 | TP53 (0.46) | TP53CALM1TSHRALDH1A1IDO1 | |
| Hydrochloric Acid SCHEMBL3654314 | 0.94 | TP53 (0.46) | TP53CALM1TSHRALDH1A1IDO1 | |
| SCHEMBL150474 | 0.73 | ALDH1A1 (0.50) | TP53CALM1TSHRALDH1A1IDO1 | |
| Hydrochloric Acid SCHEMBL29262829 | 0.71 | ALDH1A1 (0.48) | TP53CALM1TSHRALDH1A1IDO1 | |
| Dimethylamine SCHEMBL6906475 | 0.70 | KDM4E (0.48) | TP53CALM1TSHRALDH1A1IDO1 | |
| SCHEMBL5139750 | 0.70 | TP53 (0.50) | TP53CALM1TSHRALDH1A1IDO1 | |
| SCHEMBL141796 | 0.69 | — | — | |
| SCHEMBL4251511 | 0.69 | — | — | |
| SCHEMBL1768 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7291654-B2 | Storage stability of photoinitiators | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2007-11-06 | — | — | US | disclosed |
| EP-1556365-B1 | IMPROVEMENT IN THE STORAGE STABILITY OF PHOTOINITIATORS | CIBA SC HOLDING AG (CH) | 2006-08-30 | — | — | EP | disclosed |
| US-20060100298-A1 | Storage stability of photoinitiators | IGM GROUP B.V. (NL) | 2006-05-11 | — | — | US | disclosed |
| EP-1556365-A1 | IMPROVEMENT IN THE STORAGE STABILITY OF PHOTOINITIATORS | Ciba SC Holding AG (CH) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004037799-A1 | IMPROVEMENT IN THE STORAGE STABILITY OF PHOTOINITIATORS | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2004-05-06 | — | — | WO | disclosed |