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SCHEMBL5633950

SCHEMBL5633950

CC(=O)N1CCC(S(=O)(=O)NCc2nonc2C(=NOC(=O)C(F)(F)F)Nc2ccc(F)c(Cl)c2)CC1

nearest known ligand 0.37

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ RORC P51449 3/20 0.37
▸ ALDH1A1 P00352 2/20 0.36
▸ LMNA P02545 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ IDO1 P14902 2/20 0.36
▸ MAPT P10636 5/20 0.35
▸ TP53 P04637 1/20 0.35
▸ EGFR P00533 1/20 0.35
▸ MEN1 O00255 2/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ HCRTR1 O43613 1/20 0.34
▸ HCRTR2 O43614 1/20 0.34
▸ MCHR1 Q99705 2/20 0.34
▸ CNR1 P21554 1/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.34
▸ GPR35 Q9HC97 1/20 0.34
▸ GPR55 Q9Y2T6 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5631789 0.91 IDO1 (0.38) RORCSMN1; SMN2IDO1MAPTTP53
SCHEMBL5632644 0.90 IDO1 (0.39) RORCALDH1A1LMNASMN1; SMN2IDO1
Trifluoroacetic Acid SCHEMBL5633955 0.89 IDO1 (0.38) RORCALDH1A1LMNASMN1; SMN2IDO1
SCHEMBL4979135 0.88 RORC (0.36) RORCALDH1A1SMN1; SMN2IDO1MEN1
SCHEMBL14462318 0.87 IDO1 (0.37) RORCALDH1A1LMNASMN1; SMN2IDO1
SCHEMBL14462455 0.86 SMN1; SMN2 (0.40) RORCALDH1A1LMNASMN1; SMN2IDO1
SCHEMBL5633953 0.85 IDO1 (0.42) IDO1
SCHEMBL5631977 0.82 SMN1; SMN2 (0.39) RORCLMNASMN1; SMN2IDO1MAPT
SCHEMBL5630911 0.82 IDO1 (0.43) LMNASMN1; SMN2IDO1MAPTMEN1
SCHEMBL5632645 0.82 IDO1 (0.53) IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1971583-B1 N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE INCYTE CORP (US) 2015-03-25 — — EP disclosed
US-8951536-B2 N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase INCYTE CORPORATION (US) 2015-02-10 — — US disclosed
US-20130177590-A1 N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE INCYTE CORPORATION (US) 2013-07-11 — — US disclosed
US-8450351-B2 N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase INCYTE CORPORATION (US) 2013-05-28 — — US disclosed
US-20070185165-A1 N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase INCYTE CORPORATION 2007-08-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130177590-A1 N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE IDO1, IDO2, HNMT RORC 1427/4885ALDH1A1 1216/4885LMNA 4520/4885
US-20070185165-A1 N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase IDO1, IDO2, HNMT RORC 1427/4885ALDH1A1 1216/4885LMNA 4520/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.