Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.37 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5634808 | 1.00 | DRD2 (0.38) | DRD2HTR2AHTR2CTSHRCHRNB4 | |
| SCHEMBL1912803 | 1.00 | DRD2 (0.38) | DRD2HTR2AHTR2CTSHRCHRNB4 | |
| SCHEMBL5634802 | 1.00 | DRD2 (0.38) | DRD2HTR2AHTR2CTSHRCHRNB4 | |
| SCHEMBL647655 | 0.92 | CHRNB4 (0.36) | TSHRCHRNB4CHRNA3CHRNB1CHRNB2 | |
| SCHEMBL647654 | 0.92 | CHRNB4 (0.36) | TSHRCHRNB4CHRNA3CHRNB1CHRNB2 | |
| SCHEMBL647653 | 0.92 | CHRNB4 (0.36) | TSHRCHRNB4CHRNA3CHRNB1CHRNB2 | |
| SCHEMBL1913620 | 0.89 | TSHR (0.38) | TSHRCHRNB4CHRNA3CHRNB1CHRNB2 | |
| SCHEMBL1912801 | 0.74 | TSHR (0.41) | TSHRKDM4EALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL650936 | 0.74 | TSHR (0.41) | TSHRKDM4EALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL1912804 | 0.73 | TSHR (0.38) | DRD2HTR2AHTR2CTSHRCHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-20040116424-A1 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION | 2004-06-17 | — | — | US | disclosed |