Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 4/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | CHRNB1 | P11230 | 3/20 | 0.36 |
| ▸ | CHRNB3 | Q05901 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL647654 | 1.00 | CHRNB4 (0.36) | CHRNB4CHRNA3CHRNB2TSHRCHRNB1 | |
| SCHEMBL647655 | 1.00 | CHRNB4 (0.36) | CHRNB4CHRNA3CHRNB2TSHRCHRNB1 | |
| SCHEMBL1912803 | 0.92 | DRD2 (0.38) | CHRNB4CHRNA3CHRNB2TSHRCHRNB1 | |
| SCHEMBL5634810 | 0.92 | DRD2 (0.38) | CHRNB4CHRNA3CHRNB2TSHRCHRNB1 | |
| SCHEMBL5634808 | 0.92 | DRD2 (0.38) | CHRNB4CHRNA3CHRNB2TSHRCHRNB1 | |
| SCHEMBL5634802 | 0.92 | DRD2 (0.38) | CHRNB4CHRNA3CHRNB2TSHRCHRNB1 | |
| SCHEMBL1913620 | 0.88 | TSHR (0.38) | CHRNB4CHRNA3CHRNB2TSHRCHRNB1 | |
| SCHEMBL650936 | 0.74 | TSHR (0.41) | TSHRKDM4EALDH1A1CYP3A4HPGD | |
| SCHEMBL1912801 | 0.74 | TSHR (0.41) | TSHRKDM4EALDH1A1CYP3A4HPGD | |
| SCHEMBL651962 | 0.70 | TSHR (0.54) | TSHRKDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-20070208048-A1 | New Aryl Imidazoles and Related Compounds as C5a Receptor Modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2007-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070208048-A1 | New Aryl Imidazoles and Related Compounds as C5a Receptor Modulators | C3AR1, C5AR1, C5AR2 | CHRNB4 589/4885CHRNA3 423/4885CHRNB2 479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.