Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.48 |
| ▸ | PRNP | P04156 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.43 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11553918 | 0.82 | MAPK1 (0.54) | SMN1; SMN2L3MBTL1MAPTLMNAMAPK1 | |
| SCHEMBL553588 | 0.78 | KLKB1 (0.49) | SMN1; SMN2L3MBTL1MAPTRXFP1PRNP | |
| SCHEMBL5634485 | 0.77 | LMNA (0.44) | SMN1; SMN2L3MBTL1MAPTLMNAALDH1A1 | |
| SCHEMBL28987843 | 0.77 | SMN1; SMN2 (0.67) | SMN1; SMN2L3MBTL1MAPTTSHRALDH1A1 | |
| SCHEMBL92379 | 0.77 | MAPK1 (0.57) | SMN1; SMN2L3MBTL1MAPTLMNAMAPK1 | |
| SCHEMBL562969 | 0.76 | LMNA (0.46) | SMN1; SMN2L3MBTL1MAPTRXFP1PRNP | |
| SCHEMBL8132473 | 0.76 | SMN1; SMN2 (0.52) | SMN1; SMN2L3MBTL1MAPTRXFP1PRNP | |
| SCHEMBL11550439 | 0.76 | ALDH1A1 (0.55) | SMN1; SMN2L3MBTL1MAPTLMNAMAPK1 | |
| SCHEMBL20020153 | 0.75 | SMN1; SMN2 (0.38) | SMN1; SMN2MAPK1TSHR | |
| SCHEMBL10264767 | 0.74 | MAPK1 (0.55) | SMN1; SMN2L3MBTL1MAPTLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7217714-B1 | CCR5 modulators | AGOURON PHARMACEUTICALS, INC. (US) | 2007-05-15 | — | — | US | disclosed |
| CN-1150192-C | Piperidines as CCR5 modulators | — | 2004-05-19 | — | — | CN | disclosed |
| CN-1331691-A | Piperidines as CCR5 modulators | PFIZER LTD (US) | 2002-01-16 | — | — | CN | disclosed |