Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 6/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 3/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5637607 | 1.00 | USP30 (0.40) | USP30IDO1TDO2PDE4BFPR2 | |
| SCHEMBL5637688 | 0.94 | USP30 (0.42) | USP30IDO1TDO2GPR119RECQL | |
| SCHEMBL5635404 | 0.87 | USP30 (0.39) | USP30FPR2GPR119RECQLMAPT | |
| SCHEMBL5636694 | 0.85 | USP30 (0.53) | USP30GPR119MAPT | |
| SCHEMBL5636127 | 0.84 | HTR2A (0.45) | USP30GPR119HTR2AHTR2C | |
| SCHEMBL5846934 | 0.83 | NPC1 (0.41) | USP30IDO1TDO2PDE4BFPR2 | |
| SCHEMBL5847677 | 0.83 | NPC1 (0.41) | USP30IDO1TDO2PDE4BFPR2 | |
| SCHEMBL5848322 | 0.82 | NPC1 (0.40) | USP30IDO1TDO2PDE4BFPR2 | |
| SCHEMBL5848121 | 0.82 | NPC1 (0.40) | USP30IDO1TDO2PDE4BFPR2 | |
| SCHEMBL5847999 | 0.82 | NPC1 (0.40) | USP30IDO1TDO2PDE4BFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39679-E1 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2007-06-05 | — | — | US | disclosed |
| US-6713471-B1 | SUCH AS TERT-BUTYL-1-METHYL-6,7,9,12-TETRAHYDRO-5H-PYRIDO-(4,3-B)(1,4) THIAZEPINO(2,3,4-HI)INDOLE-11(10H)-CARBOXYLATE; SEROTONIN AGONISTS AND ANTAGONISTS; CENTRAL NERVOUS SYSTEM DISORDERS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-03-30 | — | — | US | disclosed |