Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.40 |
| ▸ | FPR2 | P25090 | 3/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 5/20 | 0.36 |
| ▸ | HTR2C | P28335 | 5/20 | 0.36 |
| ▸ | DRD2 | P14416 | 4/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | FNTB | P49356 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5846934 | 1.00 | NPC1 (0.41) | NPC1RAB9AUSP30FPR2IDO1 | |
| SCHEMBL5848121 | 0.97 | NPC1 (0.40) | NPC1RAB9AUSP30FPR2IDO1 | |
| SCHEMBL5847390 | 0.97 | FPR2 (0.42) | NPC1RAB9AUSP30FPR2IDO1 | |
| SCHEMBL5847999 | 0.97 | NPC1 (0.40) | NPC1RAB9AUSP30FPR2IDO1 | |
| SCHEMBL5848322 | 0.97 | NPC1 (0.40) | NPC1RAB9AUSP30FPR2IDO1 | |
| SCHEMBL5848252 | 0.94 | USP30 (0.41) | NPC1RAB9AUSP30FPR2IDO1 | |
| SCHEMBL5421540 | 0.94 | USP30 (0.41) | NPC1RAB9AUSP30FPR2IDO1 | |
| SCHEMBL5847231 | 0.87 | GPR119 (0.41) | NPC1RAB9AUSP30FPR2IDO1 | |
| SCHEMBL6491629 | 0.85 | USP30 (0.42) | USP30FPR2IDO1TDO2GPR119 | |
| SCHEMBL6491628 | 0.85 | USP30 (0.42) | USP30FPR2IDO1TDO2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7081455-B2 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-25 | — | — | US | disclosed |