Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.57 |
| ▸ | FLT1 | P17948 | 7/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.54 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.54 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6030809 | 0.92 | KDR (0.58) | KDRFLT1BLMGRM4MEN1 | |
| SCHEMBL16628086 | 0.92 | KDR (0.68) | KDRFLT1BLMMEN1KMT2A | |
| SCHEMBL3544690 | 0.90 | RAF1 (0.61) | KDRFLT1BLMKCNJ5KCNJ3 | |
| SCHEMBL5634874 | 0.85 | RAF1 (0.61) | KDRFLT1MEN1KMT2APDGFRB | |
| SCHEMBL26546756 | 0.84 | KDR (0.76) | KDRKCNJ5KCNJ3GRM4MEN1 | |
| SCHEMBL3551571 | 0.82 | KDR (0.62) | KDRFLT1BLMGRM4MAPT | |
| SCHEMBL3551573 | 0.82 | KDR (0.62) | KDRFLT1BLMGRM4MAPT | |
| SCHEMBL16620661 | 0.79 | KDR (0.72) | KDRKCNJ5KCNJ3MEN1KMT2A | |
| SCHEMBL5634693 | 0.79 | RET (0.61) | KDRFLT1MEN1KMT2APDGFRB | |
| SCHEMBL3539364 | 0.78 | RAF1 (0.74) | KDRFLT1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641759-B1 | MALONAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-03-12 | — | — | EP | disclosed |
| EP-1641759-B1 | MALONAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-03-12 | — | — | EP | disclosed |
| US-20070213374-A1 | Malonamide Derivatives | MERCK PATENT GMBH (DE) | 2007-09-13 | — | — | US | disclosed |
| US-20070213374-A1 | Malonamide Derivatives | MERCK PATENT GMBH (DE) | 2007-09-13 | — | — | US | disclosed |
| US-20070213374-A1 | Malonamide Derivatives | MERCK PATENT GMBH (DE) | 2007-09-13 | — | — | US | disclosed |
| EP-1641759-A2 | MALONAMIDE DERIVATIVES | MERCK PATENT GmbH (DE) | 2006-04-05 | — | — | EP | disclosed |
| WO-2005005389-A2 | MALONAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2005-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213374-A1 | Malonamide Derivatives | RAF1, BRAF, ARAF | KDR 1261/4885FLT1 521/4885BLM 3057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.