Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.58 |
| ▸ | FLT1 | P17948 | 7/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.53 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16628086 | 0.93 | KDR (0.68) | KDRFLT1BLMMEN1KMT2A | |
| SCHEMBL5635453 | 0.92 | KDR (0.57) | KDRFLT1BLMGRM4PDK1 | |
| SCHEMBL3544690 | 0.86 | RAF1 (0.61) | KDRFLT1BLMSMN1; SMN2HPGD | |
| SCHEMBL3551571 | 0.83 | KDR (0.62) | KDRFLT1BLMGRM4PDGFRB | |
| SCHEMBL3551573 | 0.83 | KDR (0.62) | KDRFLT1BLMGRM4PDGFRB | |
| SCHEMBL6030563 | 0.83 | RAF1 (0.64) | KDRFLT1PDGFRBKITMEN1 | |
| SCHEMBL16620661 | 0.80 | KDR (0.72) | KDRSMN1; SMN2NPSR1MEN1KMT2A | |
| SCHEMBL28325011 | 0.79 | KDR (0.69) | KDRGRM4PDK1SMN1; SMN2NPSR1 | |
| SCHEMBL13300975 | 0.77 | KDR (0.76) | KDRFLT1PDGFRBKITMEN1 | |
| SCHEMBL1790420 | 0.77 | CA1 (0.67) | KDRFLT1BLMTRPV1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060189665-A1 | Oxamide derivatives useful as raf-kinase inhibitors | MERCK PATENT GMBH (DE) | 2006-08-24 | — | — | US | disclosed |
| EP-1606260-A1 | OXAMIDE DERIVATIVES USEFUL AS RAF-KINASE INHIBITORS | MERCK PATENT GmbH (DE) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004085399-A1 | OXAMIDE DERIVATIVES USEFUL AS RAF-KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2004-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060189665-A1 | Oxamide derivatives useful as raf-kinase inhibitors | BRAF, RAF1, ARAF | KDR 474/4885FLT1 300/4885BLM 2875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.