Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 5/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.56 |
| ▸ | SCD | O00767 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.52 |
| ▸ | DHODH | Q02127 | 2/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.52 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | FHIT | P49789 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL179109 | 0.90 | METAP2 (0.60) | CHEK2KDM4EHPGDALDH1A1KMT2A | |
| SCHEMBL3921720 | 0.89 | CHEK2 (0.83) | CHEK2KDM4EHPGDALDH1A1TGFBR1 | |
| SCHEMBL3560621 | 0.86 | KDM4E (0.66) | CHEK2KDM4EHPGDALDH1A1KMT2A | |
| SCHEMBL8611783 | 0.86 | KDM4E (0.69) | CHEK2KDM4EHPGDALDH1A1KMT2A | |
| SCHEMBL28930292 | 0.85 | KDM4E (0.68) | CHEK2KDM4EHPGDALDH1A1KMT2A | |
| SCHEMBL7602620 | 0.84 | KDM4E (0.70) | CHEK2KDM4EHPGDALDH1A1KMT2A | |
| SCHEMBL1664016 | 0.83 | MMP2 (0.66) | CHEK2KDM4EHPGDALDH1A1KMT2A | |
| SCHEMBL11034496 | 0.81 | METAP1 (0.58) | CHEK2KDM4EHPGDALDH1A1KMT2A | |
| SCHEMBL20982594 | 0.80 | NR4A2 (0.77) | CHEK2KDM4EHPGDALDH1A1KMT2A | |
| SCHEMBL6220033 | 0.80 | PKN1 (0.60) | CHEK2KDM4EHPGDALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271261-B2 | Substituted benzimidazoles and imidazo-[4,5]-pyridines | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2007-09-18 | — | — | US | claimed |
| US-7271261-B2 | Substituted benzimidazoles and imidazo-[4,5]-pyridines | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2007-09-18 | — | — | US | disclosed |