Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5636711 | 0.82 | PNMT (0.34) | HTR2CHTR2AMEN1KMT2AMAPT | |
| SCHEMBL5637197 | 0.81 | HTR2C (0.32) | HTR2CMCHR1 | |
| SCHEMBL5635522 | 0.77 | HTR2C (0.34) | HTR2CHTR2AHTR2BMEN1KMT2A | |
| SCHEMBL5636929 | 0.77 | HTR2C (0.37) | HTR2CHTR2AMEN1KMT2AMAPT | |
| SCHEMBL5638608 | 0.77 | HTR2C (0.50) | HTR2CHTR2AMEN1KMT2AMAPT | |
| SCHEMBL5638181 | 0.74 | ESR2 (0.37) | HPGDMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL5635418 | 0.73 | PNMT (0.35) | HTR2CHTR2AHTR2BMEN1KMT2A | |
| SCHEMBL5635399 | 0.73 | HTR2C (0.39) | HTR2CHTR2AHTR2BMEN1KMT2A | |
| SCHEMBL5636305 | 0.72 | HTR2C (0.48) | HTR2CHTR2AHTR2BMEN1KMT2A | |
| SCHEMBL6497657 | 0.71 | HTR2C (0.38) | HTR2CHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39679-E1 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2007-06-05 | — | — | US | disclosed |
| US-6713471-B1 | SUCH AS TERT-BUTYL-1-METHYL-6,7,9,12-TETRAHYDRO-5H-PYRIDO-(4,3-B)(1,4) THIAZEPINO(2,3,4-HI)INDOLE-11(10H)-CARBOXYLATE; SEROTONIN AGONISTS AND ANTAGONISTS; CENTRAL NERVOUS SYSTEM DISORDERS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-03-30 | — | — | US | disclosed |