Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 7/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17946171 | 0.81 | ALDH1A1 (0.46) | POLBRAB9AMAPTALDH1A1TP53 | |
| SCHEMBL5511861 | 0.80 | MAPT (0.36) | RAB9AMAPTALDH1A1TP53MEN1 | |
| SCHEMBL5636878 | 0.76 | ALDH1A1 (0.57) | POLBRAB9AMAPTLMNAALDH1A1 | |
| SCHEMBL5637075 | 0.75 | NOTUM (0.45) | MAPTLMNATP53SMN1; SMN2KDM4E | |
| SCHEMBL7261348 | 0.70 | ALDH1A1 (0.58) | ALDH1A1TP53MEN1KMT2AKDM4E | |
| SCHEMBL11434570 | 0.69 | ALDH1A1 (0.53) | POLBRAB9AMAPTLMNAALDH1A1 | |
| SCHEMBL7262642 | 0.67 | ALDH1A1 (0.58) | POLBMAPTALDH1A1TP53MEN1 | |
| SCHEMBL15241785 | 0.67 | LMNA (0.43) | POLBRAB9AMAPTLMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL5636567 | 0.66 | NOTUM (0.50) | POLBMAPTLMNAALDH1A1TP53 | |
| SCHEMBL13068586 | 0.66 | ALDH1A1 (0.49) | RAB9AALDH1A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39679-E1 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2007-06-05 | — | — | US | disclosed |
| US-6713471-B1 | SUCH AS TERT-BUTYL-1-METHYL-6,7,9,12-TETRAHYDRO-5H-PYRIDO-(4,3-B)(1,4) THIAZEPINO(2,3,4-HI)INDOLE-11(10H)-CARBOXYLATE; SEROTONIN AGONISTS AND ANTAGONISTS; CENTRAL NERVOUS SYSTEM DISORDERS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-03-30 | — | — | US | disclosed |