Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 19/20 | 0.48 |
| ▸ | HTR2A | P28223 | 17/20 | 0.48 |
| ▸ | DRD2 | P14416 | 16/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5638600 | 0.91 | HTR2C (0.47) | HTR2CHTR2ADRD2HTR2B | |
| SCHEMBL5637022 | 0.88 | DRD2 (0.44) | HTR2CHTR2ADRD2 | |
| SCHEMBL5638593 | 0.87 | HTR2C (0.43) | HTR2CHTR2ADRD2HTR2B | |
| SCHEMBL5636550 | 0.86 | HTR2C (0.49) | HTR2CHTR2ADRD2 | |
| SCHEMBL5637084 | 0.82 | HTR2C (0.43) | HTR2CHTR2ADRD2HTR2B | |
| SCHEMBL5638309 | 0.81 | HTR2C (0.62) | HTR2CHTR2ADRD2HTR2BMEN1 | |
| SCHEMBL5635914 | 0.79 | DRD2 (0.42) | HTR2CHTR2ADRD2 | |
| SCHEMBL5638937 | 0.79 | HTR2A (0.63) | HTR2CHTR2ADRD2HTR2B | |
| SCHEMBL5635968 | 0.76 | HTR2C (0.49) | HTR2CHTR2ADRD2HTR2B | |
| SCHEMBL5637067 | 0.76 | DRD2 (0.39) | HTR2CHTR2ADRD2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39679-E1 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2007-06-05 | — | — | US | disclosed |