Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.40 |
| ▸ | KDR | P35968 | 4/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.37 |
| ▸ | PLK4 | O00444 | 2/20 | 0.37 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | AKT2 | P31751 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5520438 | 0.89 | PIM1 (0.39) | KMT2APDGFRBKDRFGFR1RET | |
| SCHEMBL5642412 | 0.83 | MEN1 (0.42) | MEN1KMT2APDGFRBKDRFGFR1 | |
| SCHEMBL2115891 | 0.80 | MEN1 (0.48) | MEN1KMT2APDGFRBKDRFGFR1 | |
| SCHEMBL2117957 | 0.78 | MEN1 (0.46) | MEN1KMT2APDGFRBKDRFGFR1 | |
| SCHEMBL2116963 | 0.78 | PDGFRB (0.46) | MEN1KMT2APDGFRBKDRFGFR1 | |
| SCHEMBL2112008 | 0.77 | PDGFRB (0.42) | MEN1KMT2APDGFRBKDRFGFR1 | |
| SCHEMBL2116323 | 0.75 | KDR (0.45) | MEN1KMT2APDGFRBKDRFGFR1 | |
| SCHEMBL6722350 | 0.74 | KDR (0.51) | PDGFRBKDRFGFR1RETALK | |
| SCHEMBL6734453 | 0.74 | LRRK2 (0.41) | PDGFRBKDRFGFR1RETALK | |
| SCHEMBL5641003 | 0.72 | LRRK2 (0.41) | PDGFRBKDRRETALKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179910-B2 | 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors | AGOURON PHARMACEUTICALS, INC. (US) | 2007-02-20 | — | — | US | disclosed |