Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 8/20 | 0.40 |
| ▸ | FLT1 | P17948 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 3/20 | 0.38 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.38 |
| ▸ | RIOK2 | Q9BVS4 | 2/20 | 0.38 |
| ▸ | TLK1 | Q9UKI8 | 2/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.38 |
| ▸ | PLK4 | O00444 | 2/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.38 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.38 |
| ▸ | STK25 | O00506 | 1/20 | 0.38 |
| ▸ | CIT | O14578 | 1/20 | 0.38 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6722350 | 0.91 | KDR (0.51) | KDRFLT1PDGFRBFGFR1LRRK2 | |
| SCHEMBL6734453 | 0.91 | LRRK2 (0.41) | KDRFLT1PDGFRBFGFR1LRRK2 | |
| SCHEMBL5640837 | 0.89 | PDGFRB (0.43) | MEN1KMT2AKDRFLT1PDGFRB | |
| SCHEMBL5639627 | 0.83 | MEN1 (0.42) | MEN1KMT2AKDRPDGFRBFGFR1 | |
| SCHEMBL2117957 | 0.82 | MEN1 (0.46) | MEN1KMT2AKDRPDGFRBFGFR1 | |
| SCHEMBL2113633 | 0.81 | MEN1 (0.41) | MEN1KMT2AKDRFLT1PDGFRB | |
| SCHEMBL6727036 | 0.80 | KDR (0.53) | MEN1KMT2AKDRFLT1PDGFRB | |
| SCHEMBL2115891 | 0.79 | MEN1 (0.48) | MEN1KMT2AKDRPDGFRBFGFR1 | |
| SCHEMBL2118661 | 0.77 | KDR (0.41) | MEN1KMT2AKDRFLT1PDGFRB | |
| SCHEMBL2116963 | 0.77 | PDGFRB (0.46) | MEN1KMT2AKDRPDGFRBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179910-B2 | 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors | AGOURON PHARMACEUTICALS, INC. (US) | 2007-02-20 | — | — | US | disclosed |