Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.41 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | TGM2 | P21980 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5642726 | 0.91 | ALK (0.46) | LRRK2PDGFRBEGFRFLT4KDR | |
| SCHEMBL6734453 | 0.81 | LRRK2 (0.41) | LRRK2ZAP70IDO1TDO2TGM2 | |
| SCHEMBL2113945 | 0.77 | LRRK2 (0.45) | LRRK2ZAP70IDO1TDO2TGM2 | |
| SCHEMBL5520438 | 0.73 | PIM1 (0.39) | ZAP70TGM2PDGFRBFLT4KDR | |
| SCHEMBL5640837 | 0.73 | PDGFRB (0.43) | ZAP70PDGFRBERBB2FLT4KDR | |
| SCHEMBL5639627 | 0.72 | MEN1 (0.42) | TGM2PDGFRBEGFRKDRRET | |
| SCHEMBL5642508 | 0.72 | MDM2 (0.36) | LRRK2ZAP70IDO1TDO2TGM2 | |
| SCHEMBL5642412 | 0.72 | MEN1 (0.42) | LRRK2PDGFRBEGFRFLT4KDR | |
| SCHEMBL6722350 | 0.72 | KDR (0.51) | LRRK2PDGFRBEGFRFLT4KDR | |
| SCHEMBL5518078 | 0.69 | ALK (0.50) | LRRK2PDGFRBEGFRFLT4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179910-B2 | 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors | AGOURON PHARMACEUTICALS, INC. (US) | 2007-02-20 | — | — | US | disclosed |