Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | GABRP | O00591 | 1/20 | 0.31 |
| ▸ | GABRD | O14764 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17205759 | 0.82 | KDM4E (0.37) | KDM4EALDH1A1HPGDHSD17B10RXRA | |
| SCHEMBL28938014 | 0.77 | CLCN2 (0.42) | KDM4EALDH1A1HPGDHSD17B10HSD11B1 | |
| SCHEMBL2578858 | 0.77 | MAPT (0.43) | KDM4EALDH1A1HPGDHSD17B10MRGPRX4 | |
| SCHEMBL7929322 | 0.77 | KDM4E (0.55) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL5159925 | 0.76 | HSD17B10 (0.39) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL23925909 | 0.76 | ATM (0.33) | CXCR2CXCR1 | |
| SCHEMBL5738308 | 0.75 | MRGPRX4 (0.37) | KDM4EALDH1A1HPGDHSD17B10CXCR2 | |
| SCHEMBL1811629 | 0.75 | PTGS1 (0.41) | ALDH1A1RXRARXRBCXCR2HSD11B1 | |
| SCHEMBL15226463 | 0.74 | KDM4E (0.36) | KDM4EALDH1A1HPGDHSD17B10RXRA | |
| SCHEMBL7133685 | 0.74 | NOTUM (0.41) | KDM4EALDH1A1HPGDHSD17B10CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205313-B2 | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 2007-04-17 | — | — | US | disclosed |