Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 9/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | ILK | Q13418 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5641494 | 0.78 | NTRK1 (0.64) | NTRK1JAK2MAPTPOLBALDH1A1 | |
| SCHEMBL5640367 | 0.75 | NTRK1 (0.49) | NTRK1JAK2ILKMAP4K4CDK5 | |
| SCHEMBL11751351 | 0.72 | NTRK1 (0.46) | NTRK1 | |
| SCHEMBL5637836 | 0.69 | NTRK1 (0.61) | NTRK1JAK2NPC1RAB9A | |
| SCHEMBL5637585 | 0.69 | NTRK1 (0.56) | NTRK1JAK2POLB | |
| SCHEMBL5291980 | 0.68 | ILK (0.52) | NTRK1JAK2ILKMAPTPOLB | |
| SCHEMBL5641273 | 0.68 | NTRK1 (0.66) | NTRK1JAK2ILKNPC1ALDH1A1 | |
| SCHEMBL5642992 | 0.67 | NTRK1 (1.00) | NTRK1NPC1RAB9A | |
| SCHEMBL5641550 | 0.66 | NTRK1 (0.51) | NTRK1 | |
| SCHEMBL1579154 | 0.64 | JAK2 (0.53) | JAK2MAPTPOLBNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7276602-B2 | Isothiazole derivatives useful as anticancer agents | PFIZER INC (US) | 2007-10-02 | — | — | US | disclosed |
| EP-1527071-A1 | ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2005-05-04 | — | — | EP | disclosed |
| US-20040152691-A1 | Isothiazole derivatives useful as anticancer agents | PFIZER INC | 2004-08-05 | — | — | US | disclosed |
| WO-2004011461-A1 | ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2004-02-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040152691-A1 | Isothiazole derivatives useful as anticancer agents | TP53, ACIN1, CDKN1A | NTRK1 4460/4885JAK2 1478/4885ILK 2974/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.