Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.35 |
| ▸ | KDR | P35968 | 9/20 | 0.34 |
| ▸ | FLT1 | P17948 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5642508 | 0.92 | MDM2 (0.36) | FLT3PDGFRBKDREGFRRET | |
| SCHEMBL5643779 | 0.90 | RET (0.38) | ALKTLK2ABL1RETLRRK2 | |
| SCHEMBL7246574 | 0.90 | RET (0.38) | ALKTLK2ABL1RETLRRK2 | |
| SCHEMBL2439012 | 0.79 | ALK (0.49) | ALKFLT3MEN1KMT2APDGFRB | |
| SCHEMBL5518078 | 0.74 | ALK (0.50) | ALKFLT3MEN1KMT2APDGFRB | |
| SCHEMBL2441251 | 0.73 | ALK (0.58) | ALKFLT3MEN1KMT2APDGFRB | |
| SCHEMBL2439011 | 0.73 | ALK (0.58) | ALKFLT3MEN1KMT2APDGFRB | |
| SCHEMBL6725660 | 0.73 | ALK (0.52) | ALKFLT3MEN1KMT2APDGFRB | |
| SCHEMBL722802 | 0.73 | ALK (0.52) | ALKFLT3MEN1KMT2APDGFRB | |
| SCHEMBL6722350 | 0.72 | KDR (0.51) | ALKFLT3PDGFRBFGFR1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179910-B2 | 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors | AGOURON PHARMACEUTICALS, INC. (US) | 2007-02-20 | — | — | US | disclosed |