Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 4/20 | 0.52 |
| ▸ | KDR | P35968 | 12/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 8/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 7/20 | 0.47 |
| ▸ | TLK2 | Q86UE8 | 4/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.44 |
| ▸ | FLT3 | P36888 | 6/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.44 |
| ▸ | CSF1R | P07333 | 6/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL722802 | 0.84 | ALK (0.52) | ALKKDRPRKAA1PRKAA2TLK2 | |
| SCHEMBL5518078 | 0.84 | ALK (0.50) | ALKKDRPRKAA1PRKAA2TLK2 | |
| SCHEMBL1673441 | 0.81 | ALK (0.52) | ALKKDRPRKAA1PRKAA2TLK2 | |
| SCHEMBL6727036 | 0.79 | KDR (0.53) | ALKKDRPRKAA1PRKAA2TLK2 | |
| SCHEMBL6722350 | 0.79 | KDR (0.51) | ALKKDRPRKAA1PRKAA2TLK2 | |
| SCHEMBL5642726 | 0.77 | ALK (0.46) | ALKKDRPRKAA1PRKAA2TLK2 | |
| SCHEMBL28900853 | 0.74 | KDR (0.56) | ALKKDRPRKAA1PRKAA2TLK2 | |
| SCHEMBL2116963 | 0.74 | PDGFRB (0.46) | ALKKDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL2114116 | 0.73 | LRRK2 (0.42) | ALKKDRPRKAA1PRKAA2PDGFRB | |
| SCHEMBL5642755 | 0.73 | ALK (0.42) | ALKKDRPRKAA1PRKAA2TLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040152759-A1 | Combination administration of an indolinone with a chemotherapeutic agent for cell proliferation disorders | SUGEN, INC. | 2004-08-05 | — | — | US | claimed |
| US-20040152759-A1 | Combination administration of an indolinone with a chemotherapeutic agent for cell proliferation disorders | SUGEN, INC. | 2004-08-05 | — | — | US | disclosed |
| US-20030130280-A1 | Treatment of acute myeloid leukemia with indolinone compounds | SUGEN, INC. | 2003-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040152759-A1 | Combination administration of an indolinone with a chemotherapeutic agent for cell proliferation disorders | MKI67, CCNA1, CCNI | ALK 4375/4885KDR 3687/4885PRKAA1 3094/4885 |
| US-20030130280-A1 | Treatment of acute myeloid leukemia with indolinone compounds | FLT3, FLI1, MCL1 | ALK 110/4885KDR 71/4885PRKAA1 1046/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.