Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | TGM2 | P21980 | 1/20 | 0.32 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7246574 | 1.00 | RET (0.38) | RETTGM2TLK2ALKLRRK2 | |
| SCHEMBL5642755 | 0.90 | ALK (0.42) | RETTLK2ALKLRRK2ABL1 | |
| SCHEMBL5642508 | 0.89 | MDM2 (0.36) | RETTGM2LRRK2 | |
| SCHEMBL5511277 | 0.72 | KDR (0.49) | RETTLK2ALKLRRK2LMNA | |
| SCHEMBL13712000 | 0.72 | KDR (0.49) | RETTLK2ALKLRRK2LMNA | |
| SCHEMBL2439012 | 0.70 | ALK (0.49) | TLK2ALK | |
| SCHEMBL5639627 | 0.66 | MEN1 (0.42) | RETTGM2ALK | |
| SCHEMBL5520438 | 0.66 | PIM1 (0.39) | RETTGM2ALKNPC1LMNA | |
| SCHEMBL2441251 | 0.65 | ALK (0.58) | RETTLK2ALKLRRK2LMNA | |
| SCHEMBL2439011 | 0.65 | ALK (0.58) | RETTLK2ALKLRRK2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179910-B2 | 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors | AGOURON PHARMACEUTICALS, INC. (US) | 2007-02-20 | — | — | US | disclosed |