Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | CASP1 | P29466 | 1/20 | 0.65 |
| ▸ | CASP7 | P55210 | 1/20 | 0.65 |
| ▸ | KLK6 | Q92876 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.53 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.53 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.53 |
| ▸ | KLK7 | P49862 | 1/20 | 0.53 |
| ▸ | KLK14 | Q9P0G3 | 1/20 | 0.53 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20037195 | 0.95 | MAPT (0.59) | ALDH1A1KDM4EMAPTGAACASP1 | |
| SCHEMBL31487317 | 0.86 | KDM4E (0.68) | ALDH1A1KDM4EMAPTGAACASP1 | |
| SCHEMBL1165573 | 0.86 | KDM4E (0.68) | ALDH1A1KDM4EMAPTGAACASP1 | |
| SCHEMBL12571293 | 0.86 | KDM4E (0.55) | ALDH1A1KDM4EMAPTGAACASP1 | |
| SCHEMBL20037329 | 0.85 | MAPT (0.71) | ALDH1A1KDM4EMAPTGAACASP1 | |
| SCHEMBL11014056 | 0.84 | AKR1C2 (0.68) | ALDH1A1KDM4EMAPTGAAHDAC1 | |
| SCHEMBL13802177 | 0.83 | ALDH1A1 (0.46) | ALDH1A1KDM4EMAPTGAACASP1 | |
| SCHEMBL1191332 | 0.81 | KDM4E (0.69) | ALDH1A1KDM4EMAPTGAACASP1 | |
| SCHEMBL28819182 | 0.81 | ALDH1A1 (0.54) | ALDH1A1KDM4EMAPTGAACASP1 | |
| SCHEMBL20037094 | 0.81 | KDM4E (0.61) | ALDH1A1KDM4EMAPTGAACASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7291644-B2 | Indole derivatives | ONO PHARMACEUTICALS CO., LTD. (JP) | 2007-11-06 | — | — | US | disclosed |
| US-7291644-B2 | Indole derivatives | ONO PHARMACEUTICALS CO., LTD. (JP) | 2007-11-06 | — | — | US | disclosed |
| US-7291644-B2 | Indole derivatives | ONO PHARMACEUTICALS CO., LTD. (JP) | 2007-11-06 | — | — | US | disclosed |
| US-7135495-B2 | Indole derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-11-14 | — | — | US | disclosed |
| US-20060194864-A1 | Indole derivatives | ONO PHARMACEUTICAL CO., LTD. | 2006-08-31 | — | — | US | disclosed |
| US-7098234-B2 | Indole derivatives, process for preparation of the same and use thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-08-29 | — | — | US | disclosed |
| US-20050004097-A1 | Indole derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2005-01-06 | — | — | US | disclosed |
| US-20040180885-A1 | Indole derivatives, process for preparation of the same and use thereof | ONO PHARMACEUTICAL CO., LTD. | 2004-09-16 | — | — | US | disclosed |
| EP-1424335-A1 | INDOLE DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-06-02 | — | — | EP | disclosed |
| US-6743793-B2 | DP RECEPTOR ANTAGONIST; PROSTAGLANDIN D | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-06-01 | — | — | US | disclosed |
| US-20030176400-A1 | Indole derivatives, process for preparation of the same and use thereof | ONO PHARMACEUTICALS CO., LTD. (JP) | 2003-09-18 | — | — | US | disclosed |
| EP-1262475-A1 | INDOLE DERIVATIVES, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-12-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194864-A1 | Indole derivatives | IDO1, IDO2, PTGIR | ALDH1A1 354/4885KDM4E 3234/4885MAPT 2067/4885 |
| US-20050004097-A1 | Indole derivatives | IDO1, IDO2, PTGIR | ALDH1A1 354/4885KDM4E 3234/4885MAPT 2067/4885 |
| US-20030176400-A1 | Indole derivatives, process for preparation of the same and use thereof | IDO1, KIT, ITCH | ALDH1A1 810/4885KDM4E 2893/4885MAPT 617/4885 |
| US-20040180885-A1 | Indole derivatives, process for preparation of the same and use thereof | IDO1, KIT, ITCH | ALDH1A1 810/4885KDM4E 2893/4885MAPT 617/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.